Effect of Exposure of Formaldehyde Vapours on Some Oxidative Stress Markers, Total Protein and Albumin in Albino Rats

Publication Date : 20/12/2019


Author(s) :

Olisah, M.C, Meludu S.C, Dioka C.E, Onah C.E.


Volume/Issue :
Volume 1
,
Issue 1
(12 - 2019)



Abstract :

Human exposure to formaldehyde is associated with multiple adverse effects. Its exposure may cause oxidative stress in some vital organs like liver, kidney, lungs and cardiac functions. This study was aimed to assess the effect of formaldehyde exposure to some oxidative stress markers, total protein and albumin in albino rats. Thirty male Albino Wistar rats weighing 120g – 140g were randomly divided into 3 groups: group A (control group), Group B (exposed to 100 ppm of formaldehyde for 4 weeks), Group C (exposed 200 ppm of formaldehyde for 4 weeks). The animals were exposed to formaldehyde vapors 6 hours per day using an inhalation chamber. They were sedated with chloroform after 4 weeks and 4 ml of blood samples collected for biochemical analysis using standard spectrophotometric methods. The levels of MDA were significantly higher in exposed subjects (the two weeks and four weeks post exposure (p < 0.05) when compared with the control, Also, the activities of Superoxide dismutase (SOD) and glutathione peroxidase (GPX) were significantly lower in exposed subjects (the two weeks and four weeks post exposure (p 0.05).This findings suggest that inhalation of formaldehyde vapors may induce oxidative stress.


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