ANTIBACTERIAL ACTIVITIES OF 4-BENZOYL-5-PRAZOLONE OF 2-AMINO BENZOIC ACID ( A SCHIFF BASE LIGAND) AND ITS COMPLEXES WITH SOME METALS IN THE FIRST TRANSITION SERIES

Publication Date : 16/12/2019


Author(s) :

Linus.O. Ezenweke, E.C. Okeke.


Volume/Issue :
Volume 1
,
Issue 1
(12 - 2019)



Abstract :

Reports and experience have shown that causative organisms for various illnesses develop resistance to drugs that are used for their treatment with time. This has necessitated research for new and potent drugs. Consequently in this research, a Schiff base ligand (4-benzoyl-5-pyrazolone of 2-amino benzoic acid) and its complexes with Cr, Mn, Fe, Co, Ni and Cu have been synthesized and characterized using Ir, Uv and Mass spectroscopic methods. Results showed that the mole ratio of the ligand to the metal ion in the complex is 1:1. This means that the general formula of the metal complex is M-L, where M is the metal and L is the Schiff base ligand. Results of physical tests (solubility and melting) showed that the Schiff base ligand and its metal complexes were soluble in polar solvents like di methyl sulphur oxide and dimethyl fluoride but insoluble in non-polar solvents like N-hexane and diethyl ether, the metal complexes were more stable to heat than the Schiff base ligand and the metals were comparatively more stable down the group. Results of antibacterial tests showed that the Schiff base ligand and its metal complexes were active against the growth of Staphylococuss aureus, Bacillus subtiles, Pseudononas aeruginosa and Escherichia coil and the metal complexes were more active against the growth of the organisms than the Schiff base ligand.


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